Create an infrastructure for multi-center trials ensuring compliance and high quality standards in terms of data collection and biobanking.

Harmonize available databases: study population and relevant variables.

Elaboration of guidelines document.

Focus on biomarkers based on host-pathogen interaction, technological platforms (imaging, artificial intelligence) and M/XDR molecular tests.

Describe the state of the art, advantages and pitfalls of diagnostic methods for TB and LTBI à current and future perspectives.

New drugs (repurposed/novel compounds) and host-directed therapies - preclinical testing, new approaches for clinical evaluation, methods for treatment monitoring and industry liaison.

Database of compounds/ drugs - protocols for testing efficacy in vitro and in vivo.

Describe and define treatment options and monitoring strategies - current and future perspectives.

Science communication plan.

Dissemination activities.

Website and social media accounts.

Engage new researchers, other reference networks and private partners.

Coordinate and publish the WG’s results.